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Hormone Imbalance

A simple way to describe hormone imbalance is that it represents any combination of hormone levels that are not within the expected normal range. Because hormones are kept within a certain range to perform specific functions, hormone imbalance can be associated with a variety of symptoms and functional changes in the body.

Hormone imbalance in men and women differs because of the hormones involved and the function of the hormones that are not within the normal range or not functioning properly.

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What is bHRT?

What is bHRT? Bio-Identical Hormone Replacement Therapy (bHRT) involves the use of compounds that have exactly the same chemical and molecular structure as the hormones produced in the human body. Unlike biosimilars, which may have slight structural changes due to modifications in the manufacturing process, bHRT provides hormones that are identical to those naturally occurring in the body.

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Hormone Imbalance: Men

Testosterone deficiency is present in a percentage of men age 50–69 years and in an even greater proportion of men 70 years of age and older. Unwanted consequences include decreases in: 

+ Muscle mass and strength
+ Bone mass
+ Sexual interest and ability to function sexually
+ Cognitive function

They may also experience increases in fat mass. It is unknown, however, whether these changes can all be attributed to declines in testosterone levels or whether there are other contributing factors.

Hormone Optimization: Men

A common form of hormone optimization in men is testosterone replacement therapy. This type of therapy is approved for men who have low levels of testosterone related to certain medical conditions. Examples of these conditions include genetic problems, and chemotherapy or infections that have damaged the testicles.

Hormone Imbalance: Women

Decreased estrogen levels represent an important form of hormone imbalance in women. Although in many cases it is the result of a normal physiological change associated with aging, because up to a third of a woman’s life today may occur after menopause, there is a compelling reason to be concerned about its impact on physical, social, and emotional aspects of a woman’s life, including: 

+ Physical symptoms, such as vasomotor symptoms (night sweats, hot flashes and flushes) and vaginal dryness
+ Structural changes such as bone loss, skin thinning, fatty replacement of the breast
+ Changes in blood lipids
+ Atrophy of the bladder and urethra

Hormone Optimization: Women

Hormone optimization in women usually involves some formulation of estrogen, either alone or with progesterone. As with testosterone therapy, estrogen therapy is guided by certain limitations and restrictions. Hormone therapy with estrogens (with or without progesterone) is indicated only for treatment of vasomotor symptoms and vaginal atrophy and for osteoporosis prevention or treatment. 

Testosterone is also used in women and may be appropriate treatment for those with depression and fatigue after surgically induced menopause, or in women in whom estrogen therapy hasn’t relieved all symptoms and there is a need to benefit from the effects of testosterone on the endocrine system and sexual function. Testosterone therapy comes in many forms, such as creams, gels, patches or pills.

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